The phenotypic plasticity of Cryptococcus neoformans is widely studied and demonstrated in vitro, but its influence on pathogenicity remains unclear.In this study, we investigated the dynamics of cryptococcal cell and transcriptional ORG BRAZIL NUTS remodeling during pulmonary infection in a murine model.We showed that in Cryptococcus neoformans,
The Hippo pathway was initially discovered in Drosophila melanogaster and mammals as a key regulator of tissue growth both in physiological and pathological states.Numerous Quercetin studies depict the vital role of the Hippo pathway in cardiovascular development, heart regeneration, organ size and vascular remodeling through the regulation of YAP
Mutations in Valosin Containing Protein (VCP) are associated with several degenerative diseases, including multisystem proteinopathy (MSP-1) and amyotrophic lateral sclerosis.However, patients with VCP mutations vary widely in their pathology and clinical penetrance, making it difficult to devise effective treatment strategies.A deeper understandin
Recognising the importance of the commercialisation of university intellectual property, the entrepreneurial intentions (EI) Ethernet Cable of research scientists and engineers at universities and science councils in South Africa are investigated.The study of intentions in an academic context has been recognised because of the potential of entrepre
BackgroundThe possibility of future parenthood is a highly relevant issue for patients of reproductive age facing oncologic treatment.This study aimed to investigate how fatherhood was achieved in a patient cohort of adolescents and young adults (AYAs) banking semen at time of cancer diagnosis and to determine the effectiveness of cryopreservation